Comprehensive analysis of ferritinophagy-related genes and immune infiltration landscape in diabetic retinopathy.

ABSTRACT:

Background

Diabetic retinopathy (DR) is deemed a microangiopathy and neurodegenerative disorder, which is a primary reason of visual impairment in the world. Ferritinophagy is a critical regulator of ferroptosis and has a vital part in the etiopathogenesis of DR. Nevertheless, its molecular mechanism in DR remains to be expounded.

Methods

The GSE146615 dataset was adopted to identify ferritinophagy-related differentially expressed genes (FRDEGs). The interactions and biological functions of the genes were described by means of functional enrichment analysis (FEA). The enriched gene sets were analyzed utilizing gene set enrichment analysis (GSEA) and gene set variation analysis (GSVA). Identification of hub genes was performed utilizing protein-protein interaction (PPI) analy

SUBMITTER: Yu F 

PROVIDER: S-EPMC10377661 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature