Design of Beta-2 Microglobulin Adsorbent Protein Nanoparticles.

ABSTRACT: Beta-2 microglobulin (B2M) is an immune system protein that is found on the surface of all nucleated human cells. B2M is naturally shed from cell surfaces into the plasma, followed by renal excretion. In patients with impaired renal function, B2M will accumulate in organs and tissues leading to significantly reduced life expectancy and quality of life. While current hemodialysis methods have been successful in managing electrolyte as well as small and large molecule disturbances arising in chronic renal failure, they have shown only modest success in managing plasma levels of B2M and similar sized proteins, while sparing important proteins such as albumin. We describe a systematic protein design effort aimed at adding the ability to selectively remove specific, undesired waste proteins suc

SUBMITTER: Miller JE 

PROVIDER: S-EPMC10377675 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature