Systematic Screening of Associations between Medication Use and Risk of Neurodegenerative Diseases Using a Mendelian Randomization Approach.

ABSTRACT:

Background

Systematically assessing the causal associations between medications and neurodegenerative diseases is significant in identifying disease etiology and novel therapies. Here, we investigated the putative causal associations between 23 existing medication categories and major neurodegenerative diseases (NDs), including Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS).

Methods

A two-sample mendelian randomization (MR) approach was conducted. Estimates were calculated using the inverse-variance weighted (IVW) method as the main model. A sensitivity analysis and a pleiotropy analysis were performed to identify potential violations.

Results

Genetically predisposition to antihypertensives (OR = 0.809, 95% CI = 0.668-0.981

SUBMITTER: Wang W 

PROVIDER: S-EPMC10377701 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature