Unknown

Dataset Information

0

Association between COPD and Stage of Lung Cancer Diagnosis: A Population-Based Study.


ABSTRACT: Chronic obstructive pulmonary disease (COPD) is associated with an increased risk of lung cancer; however, the association between COPD and stage of lung cancer diagnosis is unclear. We conducted a population-based cross-sectional analysis of lung cancer patients (2008-2020) in Ontario, Canada. Using estimated propensity scores and inverse probability weighting, logistic regression models were developed to assess the association between COPD and lung cancer stage at diagnosis (early: I/II, advanced: III/IV), accounting for prior chest imaging. We further examined associations in subgroups with previously diagnosed and undiagnosed COPD. Over half (55%) of all lung cancer patients in Ontario had coexisting COPD (previously diagnosed: 45%, undiagnosed at time of cancer diagnosis: 10%). Compared to people without COPD, people with COPD had 30% lower odds of being diagnosed with lung cancer in the advanced stages (OR = 0.70, 95% CI: 0.68 to 0.72). Prior chest imaging only slightly attenuated this association (OR = 0.77, 95% CI: 0.75 to 0.80). The association with lower odds of advanced-stage diagnosis remained, regardless of whether COPD was previously diagnosed (OR = 0.68, 95% CI: 0.66 to 0.70) or undiagnosed (OR = 0.77, 95% CI: 0.73 to 0.82). Although most lung cancers are detected in the advanced stages, underlying COPD was associated with early-stage detection. Lung cancer diagnostics may benefit from enhanced partnership with COPD healthcare providers.

SUBMITTER: Butler SJ 

PROVIDER: S-EPMC10377848 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature

altmetric image

Publications

Association between COPD and Stage of Lung Cancer Diagnosis: A Population-Based Study.

Butler Stacey J SJ   Louie Alexander V AV   Sutradhar Rinku R   Paszat Lawrence L   Brooks Dina D   Gershon Andrea S AS  

Current oncology (Toronto, Ont.) 20230705 7


Chronic obstructive pulmonary disease (COPD) is associated with an increased risk of lung cancer; however, the association between COPD and stage of lung cancer diagnosis is unclear. We conducted a population-based cross-sectional analysis of lung cancer patients (2008-2020) in Ontario, Canada. Using estimated propensity scores and inverse probability weighting, logistic regression models were developed to assess the association between COPD and lung cancer stage at diagnosis (early: I/II, advan  ...[more]

Similar Datasets

| S-EPMC3581486 | biostudies-other
| S-EPMC7050085 | biostudies-literature
| S-EPMC4384982 | biostudies-literature
| S-EPMC6754911 | biostudies-literature
| S-EPMC4973150 | biostudies-literature
| S-EPMC8089077 | biostudies-literature
| S-EPMC9284440 | biostudies-literature
| S-EPMC9221143 | biostudies-literature
| S-EPMC6941215 | biostudies-literature
| S-EPMC3111162 | biostudies-other