Cryobiopsy: A Breakthrough Strategy for Clinical Utilization of Lung Cancer Organoids.

ABSTRACT: One major challenge associated with lung cancer organoids (LCOs) is their predominant derivation from surgical specimens of patients with early-stage lung cancer. However, patients with advanced lung cancer, who are in need of chemotherapy, often cannot undergo surgery. Therefore, there is an urgent need to successfully generate LCOs from biopsy specimens. Conventional lung biopsy techniques, such as transthoracic needle biopsy and forceps biopsy, only yield small amounts of lung tissue, resulting in a low success rate for culturing LCOs from biopsy samples. Furthermore, potential complications, like bleeding and pneumothorax, make it difficult to obtain sufficient tissue. Another critical issue is the overgrowth of normal lung cells in later passages of LCO culture, and the optimal cultur

SUBMITTER: Park D 

PROVIDER: S-EPMC10377875 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature