A Subset of Non-Small Cell Lung Cancer Patients Treated with Pemetrexed Show ¹⁸F-Fluorothymidine "Flare" on Positron Emission Tomography.

ABSTRACT: Thymidylate synthase (TS) remains a major target for cancer therapy. TS inhibition elicits increases in DNA salvage pathway activity, detected as a transient compensatory "flare" in 3'-deoxy-3'-[¹⁸F]fluorothymidine positron emission tomography (¹⁸F-FLT PET). We determined the magnitude of the ¹⁸F-FLT flare in non-small cell lung cancer (NSCLC) patients treated with the antifolate pemetrexed in relation to clinical outcome.

Method

Twenty-one patients with advanced/metastatic non-small cell lung cancer (NSCLC) scheduled to receive palliative pemetrexed ± platinum-based chemotherapy underwent ¹⁸F-FLT PET at baseline and 4 h after initiating single-agent pemetrexed. Plasma deoxyuridine (dUrd) levels and thymidine kinase 1 (TK1) activity were m

SUBMITTER: Aravind P 

PROVIDER: S-EPMC10377924 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature