Association of cigarette smoking with risk of colorectal cancer subtypes classified by gut microbiota.

ABSTRACT:

Introduction

Both cigarette smoking and gut microbiota play important roles in colorectal carcinogenesis. We explored whether the association between smoking and colorectal cancer (CRC) risk varies by gut microbial enterotypes and how smoking-related enterotypes promote colorectal carcinogenesis.

Methods

A case-control study was conducted. Fecal microbiota was determined by 16S rDNA sequencing. The cases with CRC or adenoma were subclassified by gut microbiota enterotypes. Multivariate analyses were used to test associations between smoking and the odds of colorectal neoplasm subtypes. Mann-Whitney U tests were used to find differential genera, genes, and pathways between the subtypes.

Results

Included in the study were 130 CRC patients (type I: n=77; type II: n=53),

SUBMITTER: Cai JA 

PROVIDER: S-EPMC10377954 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature