Higher Preoperative Maximum Standardised Uptake Values (SUV_max) Are Associated with Higher Biochemical Recurrence Rates after Robot-Assisted Radical Prostatectomy for [⁶⁸Ga]Ga-PSMA-11 and [¹⁸F]DCFPyL Positron Emission Tomography/Computed Tomography.

ABSTRACT: This study aimed to investigate the association between the ⁶⁸Ga- or ¹⁸F-radiolabeled prostate-specific membrane antigen (PSMA) tracer expression, represented by the maximum standardised uptake value (SUV_max) of the dominant intraprostatic lesion, and biochemical recurrence (BCR) in primary prostate cancer (PCa) patients prior to robot-assisted radical prostatectomy (RARP). This was a retrospective, multi-centre cohort study of 446 patients who underwent [⁶⁸Ga]Ga-PSMA-11 (n = 238) or [¹⁸F]DCFPyL (n = 206) Positron Emission Tomography/Computed Tomography (PET/CT) imaging prior to RARP. SUV_max was measured in the dominant intraprostatic PCa lesions. [¹⁸F]DCFPyL patients were scanned 60 ([¹⁸F

SUBMITTER: de Bie KCC 

PROVIDER: S-EPMC10378114 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature