Laparotomy versus Peritoneal Drainage as Primary Treatment for Surgical Necrotizing Enterocolitis or Spontaneous Intestinal Perforation in Preterm Neonates: A Systematic Review and Meta-Analysis.

ABSTRACT:

Aim

to systematically review and meta-analyze the impact on morbidity and mortality of peritoneal drainage (PD) compared to laparotomy (LAP) in preterm neonates with surgical NEC (sNEC) or spontaneous intestinal perforation (SIP).

Methods

Medical databases were searched until June 2022 for studies comparing PD and LAP as primary surgical treatment of preterm neonates with sNEC or SIP. The primary outcome was survival during hospitalization; predefined secondary outcomes included need for parenteral nutrition at 90 days, time to reach full enteral feeds, need for subsequent laparotomy, duration of hospitalization and complications.

Results

Three RCTs (N = 493) and 49 observational studies (N = 19,447) were included. No differences were found in the primary outcome for

SUBMITTER: Solis-Garcia G 

PROVIDER: S-EPMC10378122 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature