High OCT4 Expression Might Be Associated with an Aggressive Phenotype in Rectal Cancer.

ABSTRACT: Rectal cancer (RC) is one of the most common malignant neoplasms, and cancer stem cells (CSCs) of the intestinal tract have been implicated in its origin. The oncofetal protein OCT4 has been linked to neoplastic processes, but its role and clinical significance in RC are unknown. This study investigates the expression of the stem cell marker OCT4 related to clinical-pathological characteristics and its clinical significance in RC patients. The expression level of stem cell marker OCT4 was analyzed in 22 primary rectal tumors by western blot. The association between OCT4 protein expression and the clinical-pathological features of tumors was evaluated by χ² test and Fisher's exact test. We demonstrated that the expression of the stem cell marker OCT4 was observed in tumor tissue

SUBMITTER: Lambis-Anaya L 

PROVIDER: S-EPMC10378144 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature