Ontology highlight
ABSTRACT:
SUBMITTER: Robinson MH
PROVIDER: S-EPMC10378152 | biostudies-literature | 2023 Aug
REPOSITORIES: biostudies-literature
Robinson M Hope MH Villa Nancy Y NY Jaye David L DL Nooka Ajay K AK Duffy Alyssa A McCachren Samuel S SS Manalo Julia J Switchenko Jeffrey M JM Barnes Sierra S Potdar Sayalee S Azeem Maryam I MI Horvat Ava A AA Parihar Vaunita C VC Gong Jingjing J Liang Yan Y Smith Geoffrey H GH Gupta Vikas A VA Boise Lawrence H LH Kaufman Jonathan L JL Hofmeister Craig C CC Joseph Nisha S NS Lonial Sagar S Dhodapkar Kavita M KM Dhodapkar Madhav V MV
The Journal of clinical investigation 20230801 15
Entry of antigen-specific T cells into human tumors is critical for immunotherapy, but the underlying mechanisms are poorly understood. Here, we combined high-dimensional spatial analyses with in vitro and in vivo modeling to study the mechanisms underlying immune infiltration in human multiple myeloma (MM) and its precursor monoclonal gammopathy of undetermined significance (MGUS). Clustered tumor growth was a feature of MM but not MGUS biopsies, and this growth pattern was reproduced in humani ...[more]