Effectiveness of Opioid Switching in Advanced Cancer Pain: A Prospective Observational Cohort Study.

ABSTRACT: Opioid switching is a common practice of substituting one opioid for another to improve analgesia or adverse effects; however, it has limited evidence. This study aimed to examine the effectiveness of opioid switching in advanced cancer. This multi-center prospective cohort study recruited patients assessed to switch opioids (opioid switch group) or to continue ongoing opioid treatment (control group). Clinical data (demographics, opioids) and validated instruments (pain and adverse effects) were collected over two timepoints seven days apart. Descriptive analyses were utilized. Non-parametric tests were used to determine differences. Fifty-four participants were recruited (23 control group, 31 switch group). At the follow-up, opioid switching reduced pain (worst, average, and now) (p</

SUBMITTER: Wong AK 

PROVIDER: S-EPMC10378198 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature