The Use of Targeted Cytokines as Cancer Therapeutics in Glioblastoma.

ABSTRACT: Cytokines play an important role in regulating the immune response. Although there is great interest in exploiting cytokines for cancer immunotherapy, their clinical potential is limited by their pleiotropic properties and instability. A variety of cancer cell-intrinsic and extrinsic characteristics pose a barrier to effective treatments including cytokines. Recent studies using gene and cell therapy offer new opportunities for targeting cytokines or their receptors, demonstrating that they are actionable targets. Current efforts such as virotherapy, systemic cytokine therapy, and cellular and gene therapy have provided novel strategies that incorporate cytokines as potential therapeutic strategies for glioblastoma. Ongoing research on characterizing the tumor microenvironment will be info

SUBMITTER: Sooreshjani M 

PROVIDER: S-EPMC10378451 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature