Global Impact of Monoclonal Antibodies (mAbs) in Children: A Focus on Anti-GD2.

ABSTRACT: Monoclonal antibodies (mAbs), as the name implies, are clonal antibodies that bind to the same antigen. mAbs are broadly used as diagnostic or therapeutic tools for neoplasms, autoimmune diseases, allergic conditions, and infections. Although most mAbs are approved for treating adult cancers, few are applicable to childhood malignancies, limited mostly to hematological cancers. As for solid tumors, only anti-disialoganglioside (GD2) mAbs are approved specifically for neuroblastoma. Inequities of drug access have continued, affecting most therapeutic mAbs globally. To understand these challenges, a deeper dive into the complex transition from basic research to the clinic, or between marketing and regulatory agencies, is timely. This review focuses on current mAbs approved or under investiga

SUBMITTER: Larrosa C 

PROVIDER: S-EPMC10378537 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature