Disruption of the Mammalian Ccr4-Not Complex Contributes to Transcription-Mediated Genome Instability.

ABSTRACT: The mammalian Ccr4-Not complex, carbon catabolite repression 4 (Ccr4)-negative on TATA-less (Not), is a large, highly conserved, multifunctional assembly of proteins that acts at different cellular levels to regulate gene expression. It is involved in the control of the cell cycle, chromatin modification, activation and inhibition of transcription initiation, control of transcription elongation, RNA export, and nuclear RNA surveillance; the Ccr4-Not complex also plays a central role in the regulation of mRNA decay. Growing evidence suggests that gene transcription has a vital role in shaping the landscape of genome replication and is also a potent source of replication stress and genome instability. Here, we have examined the effects of the inactivation of the Ccr4-Not complex, via the dep

SUBMITTER: Hagkarim NC 

PROVIDER: S-EPMC10378556 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature