Macrophage-Based Therapeutic Strategies in Hematologic Malignancies.

ABSTRACT: Macrophages are types of immune cells, with ambivalent functions in tumor growth, which depend on the specific environment in which they reside. Tumor-associated macrophages (TAMs) are a diverse population of immunosuppressive myeloid cells that play significant roles in several malignancies. TAM infiltration in malignancies has been linked to a poor prognosis and limited response to treatments, including those using checkpoint inhibitors. Understanding the precise mechanisms through which macrophages contribute to tumor growth is an active area of research as targeting these cells may offer potential therapeutic approaches for cancer treatment. Numerous investigations have focused on anti-TAM-based methods that try to eliminate, rewire, or target the functional mediators released by these

SUBMITTER: Khalili S 

PROVIDER: S-EPMC10378576 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature