Migration of Myogenic Cells Is Highly Influenced by Cytoskeletal Septin7.

ABSTRACT: Septin7 as a unique member of the GTP binding protein family, is widely expressed in the eukaryotic cells and considered to be essential in the formation of hetero-oligomeric septin complexes. As a cytoskeletal component, Septin7 is involved in many important cellular processes. However, its contribution in striated muscle physiology is poorly described. In skeletal muscle, a highly orchestrated process of migration is crucial in the development of functional fibers and in regeneration. Here, we describe the pronounced appearance of Septin7 filaments and a continuous change of Septin7 protein architecture during the migration of myogenic cells. In Septin7 knockdown C2C12 cultures, the basic parameters of migration are significantly different, and the intracellular calcium concentration cha

SUBMITTER: Raduly Z 

PROVIDER: S-EPMC10378681 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature