Prognostic significance of LRRC1 in hepatocellular carcinoma and construction of relevant prognostic model.

ABSTRACT: This study aimed to elucidate the prognostic value of the leucine rich repeat containing 1 (LRRC1) gene in hepatocellular carcinoma (HCC) and to determine the effects of high and low LRRC1 expression on mutation and immune cell infiltration. We downloaded HCC mRNA-seq expression and clinical data from University of California Santa Cruz Xena. The expression of LRRC1 was compared between HCC tumor and normal samples. Tumor samples were divided according to high and low LRRC1 expression. Differentially expressed genes between the 2 groups were identified, and function, mutation, and immune cell infiltration were analyzed. Genes associated with immune cells were identified using weighted gene co-expression network analysis, and transcription factors of these genes were predicted. Moreover, a

SUBMITTER: Cai Q 

PROVIDER: S-EPMC10378736 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature