The level of ratio between matrix metalloproteinase-1 (MMP-1) and tissue inhibitor matrix metalloproteinase-1 (TIMP-1) after prolotherapy intervention and the functional outcome in patient with frozen shoulder: A randomized controlled trial.

ABSTRACT:

Objective

To determine the effect of prolotherapy on functional outcome changes, along with ratio of matrix metalloproteinase-1 (MMP-1)/tissue inhibitor matrix metalloproteinase-1 (TIMP-1) as an indicator of tissue repair in the glenohumeral joint in frozen shoulder patients.

Design

Single-blinded randomized controlled trial.

Subjects/patients

Participants with frozen shoulder.

Methods

The prolotherapy group is the study group, and the normal saline (NS) group is the control group. Each group was given injections at weeks 0, 2, 4, and 6. Level of biomarker levels was measured at week 6 and week 12 after there. Functional outcomes were measured at weeks 0, 6, and 12.

Results

A significant difference in week 6 and week 12 was demonstrated in the ratio of M

SUBMITTER: Sam N 

PROVIDER: S-EPMC10378817 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature