Explore the mechanism of ursolic acid acting on atherosclerosis through network pharmacological and bioinformatics methods.

ABSTRACT: To explore the deep mechanisms of ursolic acid (UA) for treating atherosclerosis based on network pharmacology and bioinformatics. UA target genes were derived from traditional Chinese medicine system pharmacology, BATMAN-TCM, and SwissTargetPrediction databases. Atherosclerosis-related genes were derived from genecards, NCBI genes, and OMIM databases. The protein interaction network was constructed through the STRING database, and the hub network was extracted by using the Cytoscape software MCODE app. The enrichment analysis of gene ontology and Kyoto encyclopedia of genes and genomes was performed by the R software clusterProfiler package, and the expression and prognostic value of the hub genes were verified on the data set. Screen the genes for expression and prognosis conclusions, co

SUBMITTER: Huang N 

PROVIDER: S-EPMC10378903 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature