Context and Mutation in Gymnosperm Chloroplast DNA.

ABSTRACT: Mutations and subsequent repair processes are known to be strongly context-dependent in the flowering-plant chloroplast genome. At least six flanking bases, three on each side, can have an influence on the relative rates of different types of mutation at any given site. In this analysis, examine context and substitution at noncoding and fourfold degenerate coding sites in gymnosperm DNA. The sequences are analyzed in sets of three, allowing the inference of the substitution direction and the generation of context-dependent rate matrices. The size of the dataset limits the analysis to the tetranucleotide context of the sites, but the evidence shows that there are significant contextual effects, with patterns that are similar to those observed in angiosperms. These effects most likely repres

SUBMITTER: Morton BR 

PROVIDER: S-EPMC10378972 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature