Engineered Human Dendritic Cell Exosomes as Effective Delivery System for Immune Modulation.

ABSTRACT: Exosomes (exos) contain molecular cargo of therapeutic and diagnostic value for cancers and other inflammatory diseases, but their therapeutic potential for periodontitis (PD) remains unclear. Dendritic cells (DCs) are the directors of immune response and have been extensively used in immune therapy. We previously reported in a mouse model of PD that custom murine DC-derived exo subtypes could reprogram the immune response toward a bone-sparing or bone-loss phenotype, depending on immune profile. Further advancement of this technology requires the testing of human DC-based exos with human target cells. Our main objective in this study is to test the hypothesis that human monocyte-derived dendritic cell (MoDC)-derived exos constitute a well-tolerated and effective immune therapeutic approac

SUBMITTER: Elsayed R 

PROVIDER: S-EPMC10379002 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature