Novel Hydrophilic Oligomer-Crosslinked Gelatin-Based Hydrogels for Biomedical Applications.

ABSTRACT: Gelatin-based hydrogels have shown good injectability and biocompatibility and have been broadly used for drug delivery and tissue regeneration. However, their low mechanical strengths and fast degradation rates must be modified for long-term implantation applications. With an aim to develop mechanically stable hydrogels, reactive anhydride-based oligomers were developed and used to fabricate gelatin-based crosslinked hydrogels in this study. A cascade of hydrophilic oligomers containing reactive anhydride groups was synthesized by free radical polymerization. These oligomers varied in degree of reactivity, comonomer composition, and showed low molecular weights (M_n < 5 kDa). The reactive oligomers were utilized to fabricate hydrogels that differed in their mechanical strengths

SUBMITTER: Tariq M 

PROVIDER: S-EPMC10379017 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature