Fascin-1 in Cancer Cell Metastasis: Old Target-New Insights.

ABSTRACT: As metastasis is responsible for most cancer-related deaths, understanding the cellular and molecular events that lead to cancer cell migration and invasion will certainly provide insights into novel anti-metastatic therapeutic targets. Fascin-1 is an actin-bundling protein fundamental to all physiological or pathological processes that require cell migration. It is responsible for cross-linking actin microfilaments during the formation of actin-rich cellular structures at the leading edge of migrating cells such as filopodia, lamellipodia and invadopodia. While most epithelial tissues express low levels of Fascin-1, it is dramatically elevated in the majority of cancers and its expression has been associated with more aggressive disease and decreased overall survival. Hence, it has been p

SUBMITTER: Sarantelli E 

PROVIDER: S-EPMC10379093 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature