Metal Nanomaterials and Hydrolytic Enzyme-Based Formulations for Improved Antifungal Activity.

ABSTRACT: Active research of metal-containing compounds and enzymes as effective antifungal agents is currently being conducted due to the growing antifungal resistance problem. Metals are attracting special attention due to the wide variety of ligands that can be used for them, including chemically synthesized and naturally obtained variants as a result of the so-called "green synthesis". The main mechanism of the antifungal action of metals is the triggering of the generation and accumulation of reactive oxygen species (ROS). Further action of ROS on various biomolecules is nonspecific. Various hydrolytic enzymes (glucanases and proteases), in turn, exhibit antifungal properties by affecting the structural elements of fungal cells (cell walls, membranes), fungal quorum sensing molecules, fungal ow

SUBMITTER: Lyagin I 

PROVIDER: S-EPMC10379199 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature