Clinical and Genetic Aspects of Alopecia Areata: A Cutting Edge Review.

ABSTRACT: Alopecia areata (AA) is a chronic, non-scarring, immune-mediated skin disease that affects approximately 0.5-2% of the global population. The etiology of AA is complex and involves genetic and environmental factors, with significant advancements in genetic research occurring in recent years. In addition to well-known genes such as PTPN22, CTLA4, and IL2, which have been widely supported as being associated with AA, an increasing number of specific gene-related loci have been discovered through advances in genetic research. For instance, gene analysis of microRNAs can reveal the critical role of miRNAs in regulating gene expression, aiding in the understanding of cellular and organismal functional regulatory mechanisms. Furthermore, numerous studies have confirmed the e

SUBMITTER: Ho CY 

PROVIDER: S-EPMC10379312 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature