Alternative Splicing, RNA Editing, and the Current Limits of Next Generation Sequencing.

ABSTRACT: The advent of next generation sequencing (NGS) has fostered a shift in basic analytic strategies of a gene expression analysis in diverse pathologies for the purposes of research, pharmacology, and personalized medicine. What was once highly focused research on individual signaling pathways or pathway members has, from the time of gene expression arrays, become a global analysis of gene expression that has aided in identifying novel pathway interactions, the discovery of new therapeutic targets, and the establishment of disease-associated profiles for assessing progression, stratification, or a therapeutic response. But there are significant caveats to this analysis that do not allow for the construction of the full picture. The lack of timely updates to publicly available databases and th

SUBMITTER: Piazzi M 

PROVIDER: S-EPMC10379330 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature