A Significant Increasing Risk Association between Cigarette Smoking and XPA and XPC Genes Polymorphisms.

ABSTRACT: Cigarette smoking (CS) is a major cause of various serious diseases due to tobacco chemicals. There is evidence suggesting that CS has been linked with the DNA damage repair system, as it can affect genomic stability, inducing genetic changes in the genes involved in the repair system, specifically the nucleotide excision repair (NER) pathway, affecting the function and/or regulation of these genes. Single nucleotide polymorphism (SNP), along with CS, can affect the work of the NER pathway and, therefore, could lead to different diseases. This study explored the association of four SNPs in both XPA and XPC genes with CS in the Saudi population. The Taq Man genotyping assay was used for 220 healthy non-smokers (control) and 201 healthy smokers to evaluate four SNPs in the X

SUBMITTER: Almushawwah S 

PROVIDER: S-EPMC10379612 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature