Low catestatin as a risk factor for cardiovascular disease - assessment in patients with adrenal incidentalomas.

ABSTRACT:

Background

Catestatin (Cts) is a peptide derived from proteolytic cleavage of chromogranin A, which exhibits cardioprotective and anti-inflammatory properties. Cts has been proposed as a potential biomarker for cardiovascular (CV) disease.

Objectives

examining Cts in patients with incidentally discovered adrenocortical adenomas (AI), and its associations with CV risk factors and blood pressure (BP).

Materials and methods

In this cross-sectional study, 64 AI patients without overt CV disease other than primary hypertension were recruited along with 24 age-, sex-, and body-mass-index (BMI)-matched controls with normal adrenal morphology. Laboratory, 24-h ambulatory BP monitoring, echocardiography, and common carotid artery sonography examinations were performed.

Resu

SUBMITTER: Zalewska E 

PROVIDER: S-EPMC10379641 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature