A Combined Effect of Polygenic Scores and Environmental Factors on Individual Differences in Depression Level.

ABSTRACT: The risk of depression could be evaluated through its multifactorial nature using the polygenic score (PGS) approach. Assuming a "clinical continuum" hypothesis of mental diseases, a preliminary assessment of individuals with elevated risk for developing depression in a non-clinical group is of high relevance. In turn, epidemiological studies suggest including social/lifestyle factors together with PGS to address the "missing heritability" problem. We designed regression models, which included PGS using 27 SNPs and social/lifestyle factors to explain individual differences in depression levels in high-education students from the Volga-Ural region (VUR) of Eurasia. Since issues related to population stratification in PGS scores may lead to imprecise variant effect estimates, we aimed to exa

SUBMITTER: Kazantseva A 

PROVIDER: S-EPMC10379734 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature