Targeted Alpha-Particle Therapy: A Review of Current Trials.

ABSTRACT: Radiopharmaceuticals are rapidly developing as a field, with the successful use of targeted beta emitters in neuroendocrine tumors and prostate cancer serving as catalysts. Targeted alpha emitters are in current development for several potential oncologic indications. Herein, we review the three most prevalently studied conjugated/chelated alpha emitters (²²⁵actinium, ²¹²lead, and ²¹¹astatine) and focus on contemporary clinical trials in an effort to more fully appreciate the breadth of the current evaluation. Phase I trials targeting multiple diseases are now underway, and at least one phase III trial (in selected neuroendocrine cancers) is currently in the initial stages of recruitment. Combination trials are now also emerging as alpha emitters are integr

SUBMITTER: Jang A 

PROVIDER: S-EPMC10380274 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature