Transglutaminase 2 Facilitates Murine Wound Healing in a Strain-Dependent Manner.

ABSTRACT: Transglutaminase 2 (TG2) plays a role in cellular processes that are relevant to wound healing, but to date no studies of wound healing in TG2 knockout mice have been reported. Here, using 129T2/SvEmsJ (129)- or C57BL/6 (B6)-backcrossed TG2 knockout mice, we show that TG2 facilitates murine wound healing in a strain-dependent manner. Early healing of in vivo cutaneous wounds and closure of in vitro scratch wounds in murine embryonic fibroblast (MEF) monolayers were delayed in 129, but not B6, TG2 knockouts, relative to their wild-type counterparts, with wound closure in 129 being faster than in B6 wild-types. A single dose of exogenous recombinant wild-type TG2 to 129 TG2^-/- mice or MEFs immediately post-wounding accelerated wound closure. Neutrophil and monocyte recruitment to

SUBMITTER: Yiu TW 

PROVIDER: S-EPMC10380275 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature