2-DG Regulates Immune Imbalance on the Titanium Surface after Debridement.

ABSTRACT: Peri-implantitis requires clinical treatments comprised of mechanical and chemical debridement to remove bacterial biofilms. Bone regeneration on the titanium surface after debridement has been a topical issue of peri-implantitis treatments. Increasing evidence has revealed that the immune microenvironment plays a key role in regulating the bone regeneration process. However, it remains unclear what kind of immune microenvironment the titanium surface induces after debridement. In the study, model titanium surface after debridement was prepared via biofilm induction and mechanical and chemical debridement in vitro. Then, the macrophages and naïve CD4⁺ T lymphocytes were cultured on the titanium surface after debridement for immune microenvironment evaluation, with the original t

SUBMITTER: Liu X 

PROVIDER: S-EPMC10380309 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature