Characterization of the Cardiac Structure and Function of Conscious D2.B10-Dmd^mdx/J (D2-mdx) mice from 16-17 to 24-25 Weeks of Age.

ABSTRACT: Duchenne muscular dystrophy (DMD) is the most common form of muscle degenerative hereditary disease. Muscular replacement by fibrosis and calcification are the principal causes of progressive and severe musculoskeletal, respiratory, and cardiac dysfunction. To date, the D2.B10-Dmd^mdx/J (D2-mdx) model is proposed as the closest to DMD, but the results are controversial. In this study, the cardiac structure and function was characterized in D2-mdx mice from 16-17 up to 24-25 weeks of age. Echocardiographic assessment in conscious mice, gross pathology, and histological and cardiac biomarker analyses were performed. At 16-17 weeks of age, D2-mdx mice presented mild left ventricular function impairment and increased pulmonary vascular resistance. Cardiac

SUBMITTER: De Giorgio D 

PROVIDER: S-EPMC10380312 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature