Development of Mn²⁺-Specific Biosensor Using G-Quadruplex-Based DNA.

ABSTRACT: Metal ions are used in various situations in living organisms and as a part of functional materials. Since the excessive intake of metal ions can cause health hazards and environmental pollution, the development of new molecules that can monitor metal ion concentrations with high sensitivity and selectivity is strongly desired. DNA can form various structures, and these structures and their properties have been used in a wide range of fields, including materials, sensors, and drugs. Guanine-rich sequences respond to metal ions and form G-quadruplex structures and G-wires, which are the self-assembling macromolecules of G-quadruplex structures. Therefore, guanine-rich DNA can be applied to a metal ion-detection sensor and functional materials. In this study, the IRDAptamer library originall

SUBMITTER: Mizunuma M 

PROVIDER: S-EPMC10380348 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature