Cardiac Function and Serum Biomarkers throughout Staged Fontan Palliation: A Prospective Observational Study.

ABSTRACT: Fontan patients undergo multiple cardiothoracic surgeries in childhood. Following these procedures, ventricular function is temporarily decreased, and recovers over months. This is presumably related to cardiopulmonary bypass, but this is incompletely understood. Throughout the Fontan palliation, cardiac function is also affected by volume unloading. We aimed to gain insight into the biological processes related to impaired ventricular function and recovery following Fontan palliations using a panel of biomarkers. Furthermore, we described changes in ventricular function across the Fontan palliation due to volume unloading. We performed a prospective multicenter observational study in patients undergoing partial (PCPC) or total cavo-pulmonary connection (TCPC). Patients underwent assessmen

SUBMITTER: van der Ven JPG 

PROVIDER: S-EPMC10380373 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature