MicroRNA Expression Dynamics in Culicoides sonorensis Biting Midges Following Blood-Feeding.

ABSTRACT: Culicoides sonorensis midges vector multiple livestock arboviruses, resulting in significant economic losses worldwide. Due to the tight association between virus transmission, blood feeding, and egg development, understanding midge physiology is paramount to limiting pathogen transmission. Previous studies have demonstrated the importance of small non-coding RNAs (ncRNAs), specifically microRNAs (miRNAs), in multiple aspects of vector physiology. These small ncRNAs regulate gene expression at the post-transcriptional level and display differential expression during pathogen infection. Due to the lack of annotated miRNAs in the biting midge and associated expression profiles, we used small RNA-Seq and miRDeep2 analyses to determine the Culicoides miRNAs in whole females and m

SUBMITTER: Mills MK 

PROVIDER: S-EPMC10380374 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature