AhRR and PPP1R3C: Potential Prognostic Biomarkers for Serous Ovarian Cancer.

ABSTRACT: The lack of effective screening and successful treatment contributes to high ovarian cancer mortality, making it the second most common cause of gynecologic cancer death. Development of chemoresistance in up to 75% of patients is the cause of a poor treatment response and reduced survival. Therefore, identifying potential and effective biomarkers for its diagnosis and prognosis is a strong critical need. Copy number alterations are frequent in cancer, and relevant for molecular tumor stratification and patients' prognoses. In this study, array-CGH analysis was performed in three cell lines and derived cancer stem cells (CSCs) to identify genes potentially predictive for ovarian cancer patients' prognoses. Bioinformatic analyses of genes involved in copy number gains revealed that AhRR and

SUBMITTER: Ardizzoia A 

PROVIDER: S-EPMC10380391 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature