Liver-Support Therapies in Critical Illness-A Comparative Analysis of Procedural Characteristics and Safety.

ABSTRACT: Extracorporeal liver-support therapies remain controversial in critically ill patients, as most studies have failed to show an improvement in outcomes. However, heterogeneous timing and inclusion criteria, an insufficient number of treatments, and the lack of a situation-dependent selection of available liver-support modalities may have contributed to negative study results. We retrospectively investigated the procedural characteristics and safety of the three liver-support therapies CytoSorb, Molecular Adsorbent Recirculating System (MARS) and therapeutic plasma exchange (TPE). Whereas TPE had its strengths in a shorter treatment duration, in clearing larger molecules, affecting platelet numbers less, and improving systemic coagulation and hemodynamics, CytoSorb and MARS were associated w

SUBMITTER: Goth D 

PROVIDER: S-EPMC10380554 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature