The Roles of Histone Lysine Methyltransferases in Heart Development and Disease.

ABSTRACT: Epigenetic marks regulate the transcriptomic landscape by facilitating the structural packing and unwinding of the genome, which is tightly folded inside the nucleus. Lysine-specific histone methylation is one such mark. It plays crucial roles during development, including in cell fate decisions, in tissue patterning, and in regulating cellular metabolic processes. It has also been associated with varying human developmental disorders. Heart disease has been linked to deregulated histone lysine methylation, and lysine-specific methyltransferases (KMTs) are overrepresented, i.e., more numerous than expected by chance, among the genes with variants associated with congenital heart disease. This review outlines the available evidence to support a role for individual KMTs in heart development

SUBMITTER: Zhu JY 

PROVIDER: S-EPMC10380575 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature