Distinct Molecular Signatures of Amyloid-Beta and Tau in Alzheimer's Disease Associated with Down Syndrome.

ABSTRACT: Limited comparative data exist on the molecular spectrum of amyloid-beta (Aβ) and tau deposition in individuals with Down syndrome (DS) and sporadic Alzheimer's disease (sAD). We assessed Aβ and tau deposition severity in the temporal lobe and cerebellum of ten DS and ten sAD cases. Immunohistochemistry was performed using antibodies against eight different Aβ epitopes (6F/3D, Aβ₃₈, Aβ₃₉, Aβ₄₀, Aβ₄₂, Aβ₄₃, pyroglutamate Aβ at third glutamic acid (Aβ_Np3E), phosphorylated- (p-)Aβ at 8th serine (Aβ_pSer8)), and six different pathological tau epitopes (p-Ser202/Thr205, p-Thr231, p-Ser396, Alz50, MC1, GT38). Findings were evaluated semi-quantitatively and quantitatively using digital pathology. DS cases had significantl

SUBMITTER: Ichimata S 

PROVIDER: S-EPMC10380583 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature