Bioactive Compounds and Cardiac Fibrosis: Current Insight and Future Prospect.

ABSTRACT: Cardiac fibrosis is a pathological condition characterized by excessive deposition of collagen and other extracellular matrix components in the heart. It is recognized as a major contributor to the development and progression of heart failure. Despite significant research efforts in characterizing and identifying key molecular mechanisms associated with myocardial fibrosis, effective treatment for this condition is still out of sight. In this regard, bioactive compounds have emerged as potential therapeutic antifibrotic agents due to their anti-inflammatory and antioxidant properties. These compounds exhibit the ability to modulate fibrogenic processes by inhibiting the production of extracellular matrix proteins involved in fibroblast to myofibroblast differentiation, or by promoting thei

SUBMITTER: Majid A 

PROVIDER: S-EPMC10380727 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature