Polymorphisms of Killer Ig-like Receptors and the Risk of Glioblastoma.

ABSTRACT:

Purpose

The immune responses of natural killer (NK) cells against cancer cells vary by patient. Killer Ig-like receptors (KIRs), which are some of the major receptors involved in regulating NK cell activity for killing cancer cells, have significant genetic variation. Numerous studies have suggested a potential association between the genetic variation of KIR genes and the risk of development or prognosis of various cancer types. However, an association between genetic variations of KIR genes and glioblastoma (GB) remains uncertain. We sought to evaluate the association of genetic variations of KIRs and their ligand genes with the risk of GB development in Koreans.

Methods

A case-control study was performed to identify the odds ratios (ORs) of KIR genes and Classes A, B, and

SUBMITTER: Choi H 

PROVIDER: S-EPMC10380963 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature