Genetic diversity and drug sensitivity profile of Mycobacterium tuberculosis among children in Ethiopia.

ABSTRACT:

Background

Worldwide, tuberculosis (TB) affects about one million children every year. The burden of the disease is higher in developing countries. However, there is limited information on the lineages and drug sensitivity patterns of Mycobacterium tuberculosis (M. tuberculosis) infecting children in these countries, including Ethiopia. Thus, this study aimed to characterize the different lineages of the M. tuberculosis complex causing childhood pulmonary tuberculosis and evaluate the drug-sensitivity patterns to the first-line anti-TB drugs.

Method

A total of 54 stored cultures were used in this study. The region of difference 9 (RD9) based polymerase chain reaction (PCR) and spoligotyping were employed for the identification of the isolates at the species and lineages leve

SUBMITTER: Mollalign H 

PROVIDER: S-EPMC10381036 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature