Brain MRI segmentation of Zika-Exposed normocephalic infants shows smaller amygdala volumes.

ABSTRACT:

Background

Infants with congenital Zika syndrome (CZS) are known to exhibit characteristic brain abnormalities. However, the brain anatomy of Zika virus (ZIKV)-exposed infants, born to ZIKV-positive pregnant mothers, who have normal-appearing head characteristics at birth, has not been evaluated in detail. The aim of this prospective study is, therefore, to compare the cortical and subcortical brain structural volume measures of ZIKV-exposed normocephalic infants to age-matched healthy controls.

Methods and findings

We acquired T2-MRI of the whole brain of 18 ZIKV-exposed infants and 8 normal controls on a 3T MRI scanner. The MR images were auto-segmented into eight tissue types and anatomical regions including the white matter, cortical grey matter, deep nuclear grey matter

SUBMITTER: Ghosh S 

PROVIDER: S-EPMC10381087 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature