Unprecedented Antimicrobial and Cytotoxic Polyketides from Cultures of Diaporthe africana sp. nov.

ABSTRACT: Four unprecedented polyketides named isoprenylisobenzofuran B (2), isoprenylisobenzofuran C₁/C₂ (3), diaporisoindole F₁/F₂ (4), and isochromophilonol A₁/A₂ (7) were isolated from ethyl acetate extracts of the newly described endophytic fungus Diaporthe africana. Additionally, the previously reported cyclic depsipeptide eucalactam B (1) was also identified, along with the known compounds diaporisoindole A/B (5), tenellone B (6) and beauvericin (8). The taxonomic identification of the fungus was accomplished using a polyphasic approach combining multi-gene phylogenetic analysis and microscopic morphological characters. The structures 1-8 were determin

SUBMITTER: Matio Kemkuignou B 

PROVIDER: S-EPMC10381184 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature