Predicting Long-Term Ventricular Arrhythmia Risk in Children with Acute Lymphoblastic Leukemia Using Normal Values of Ventricular Repolarization Markers Established from Japanese Cohort Study.

ABSTRACT:

Background

Cardiac complications due to anthracycline treatment may become evident several years after chemotherapy and are recognized as a serious cause of morbidity and mortality in cancer patients or childhood cancer survivors.

Objectives

We analyzed ventricular repolarization parameters in electrocardiography for pediatric acute lymphoblastic leukemia patients during chemotherapy and in long-term follow-up. To establish the reference values of ventricular repolarization parameters in children, we retrospectively summarized the Tpe interval, QT interval, QTc interval, and Tpe/QT ratio in healthy Japanese children.

Methods

Electrocardiography data recorded from students in 1st and 7th grades were randomly selected from a database maintained by the school-based scree

SUBMITTER: Takeguchi M 

PROVIDER: S-EPMC10381239 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature