Protective Effects of Cirsium japonicum var. maackii Flower on Amyloid Beta_25-35-Treated C6 Glial Cells.

ABSTRACT: Amyloid beta (Aβ) is a neurotoxic peptide and a key factor causing Alzheimer's disease. Cirsium japonicum var. maackii (CJM) has neuroprotective effects, but the protective effects of the flower from CJM (FCJM) on the neural system remain unclear. This study aimed to identify the fraction of FCJM with the highest neuroprotective potential and investigate its protective mechanisms against Aβ_25-35-induced inflammation in C6 glial cells. The cell viability and generation of reactive oxygen species (ROS) were measured to investigate the positive effect of FCJM on oxidative stress. Treatment with the FCJM extract or fractions increased the cell viability to 60-70% compared with 52% in the Aβ_25-35-treated control group and decreased ROS production to 84% compa

SUBMITTER: Pang QQ 

PROVIDER: S-EPMC10381248 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature