Fabrication and Evaluation of Porous dECM/PCL Scaffolds for Bone Tissue Engineering.

ABSTRACT: Porous scaffolds play a crucial role in bone tissue regeneration and have been extensively investigated in this field. By incorporating a decellularized extracellular matrix (dECM) onto tissue-engineered scaffolds, bone regeneration can be enhanced by replicating the molecular complexity of native bone tissue. However, the exploration of porous scaffolds with anisotropic channels and the effects of dECM on these scaffolds for bone cells and mineral deposition remains limited. To address this gap, we developed a porous polycaprolactone (PCL) scaffold with anisotropic channels and functionalized it with dECM to capture the critical physicochemical properties of native bone tissue, promoting osteoblast cells' proliferation, differentiation, biomineralization, and osteogenesis. Our results dem

SUBMITTER: Wang W 

PROVIDER: S-EPMC10381742 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature