Integration of Physiological, Transcriptomic and Metabolomic Reveals Molecular Mechanism of Paraisaria dubia Response to Zn²⁺ Stress.

ABSTRACT: Utilizing mycoremediation is an important direction for managing heavy metal pollution. Zn²⁺ pollution has gradually become apparent, but there are few reports about its pollution remediation. Here, the Zn²⁺ remediation potential of Paraisaria dubia, an anamorph of the entomopathogenic fungus Ophiocordyceps gracilis, was explored. There was 60% Zn²⁺ removed by Paraisaria dubia mycelia from a Zn²⁺-contaminated medium. To reveal the Zn²⁺ tolerance mechanism of Paraisaria dubia, transcriptomic and metabolomic were executed. Results showed that Zn²⁺ caused a series of stress responses, such as energy metabolism inhibition, oxidative stress, antioxidant defense system disruption, autophagy obstruction,

SUBMITTER: Wang Y 

PROVIDER: S-EPMC10381912 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature